Core Expertise & Technological Platform

At the heart of Mucommune is world-class expertise in immunoengineering, drug and gene delivery, and mucosal therapeutics that enables the effective advancement of diverse technologies into clinical development.

Elleon: Advancing innovations to promote female reproductive health

First in-class platform for harnessing the synergy between antibodies and mucus to reinforce the mucus barrier for mucosal health
Proprietary platforms for on-demand or sustained delivery of small molecules to biomacromolecules
Unparalleled safety from direct vaginal delivery

Mucommune's effort in female reproductive health is supported by its portfolio of mucosal antibody IP licensed from UNC, including (i) the muco-trapping mAb platform that harnesses Fc-mucin interactions to immobilize viruses, bacteria and sperm in mucus, and (ii) the highly multivalent Ig platform. The approach has been validated against a variety of pathogens across all major mucosal secretions, with proof-of-concept in both small and large animal models.

Mucommune is adding its expertise in developing various drug delivery formats, including on-demand vaginal tablets and sustained release intravaginal rings (IVRs) that can be tailored to provide moth-long sustained release of a diverse array of therapeutics while preserving their activity. These platforms enables us to develop first-in-class interventions that can address a variety of unmet needs in female reproductive health with exceptional potency, safety, and user-friendliness.

Polyon: Enabling safer, more efficacious use of PEGylated and other polymer-modified therapeutics

PEG-specific intervention that reduces induction of anti-PEG antibodies
Restores prolonged circulation of PEGylated drugs & drug carriers
Eliminates PEG-specific hypersensitivity reactions

Polyon's patented formulation approach can prevent and overcome pre-existing anti-PEG antibodies, as validated by both rodent and swine studies. It is molecularly specific (i.e., no need for broad immunosuppression), works immediately, is compatible with existing CMC, and offers potential to extend IP of parent drugs.

Stealth in vivo cell engineering pipeline: Enables direct in vivo programming of immune cells, removing the need for cell extraction or manufacturing for more cost efficient, safe, and effective engineering of immune cells to treat cancer and autoimmune diseases.

Enables highly efficient and specific in vivo transduction and engineering of T cells and other immune cells
Eliminates the need for lymphodepletion and T-cell activation prior to treatment
Substantially reduces manufacturing complexity and costs compared to conventional ex vivo CAR-T therapies, greatly expanding patient access to treatment