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Contraceptive mAbs

  • Shrestha B, Schaefer A, Chavez E, Kopp AJ, Jacobs TM, Moench TR, Lai SK§. (2020) Engineering tetravalent IgGs with enhanced agglutination potencies for trapping vigorously motile sperm in mucin matrix. Acta Biomaterialia 117:226-234

  • Anderson D, Politch JA, Cone R, Zeitlin L, Lai SK, Santangelo PJ, Moench MR, Whaley KJ. (2020) Engineering monoclonal antibody-based contraception and multipurpose prevention technologies. Biology of Reproduction. 103(2): 275–285

  • Zhu Y, Saada J, Shrestha B, Lai SK, Villarreal P, Pyles R, Motamedi M, Vargas G, Moench T. Vincent KL. (2020) Surrogate post-coital testing for contraceptive efficacy against human sperm activity in the ovine vaginal model. Biology of Reproduction. 104(2):317-324

  • Shrestha B, Schaefer A, Zhu Y, Saada J, Jacobs TM, Chavez EC, Omsted SS, Cruz-Teran CA, Baldeon Vaca G, Vincent K, Moench TR, Lai SK§. (2021) Highly potent multimeric sperm-binding antibodies for effective female non-hormonal contraception in vivo. Science Translational Medicine. 13(606):eabd5219
    Highlighted in The Scientist, MedScape, WRAL TechWire.

Muco-trapping mAbs and Mucosal Antibody

  • Olmsted SS, Padgett JL, Yudin AI, Whaley KJ, Moench TR, Cone RA. (2001) Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys J. Oct;81(4):1930-7. 

  • Cone RA (2009) Barrier properties of mucus Adv Drug Deliv Rev. 2009 Feb 27;61(2):75-85.

  • O'Hanlon DE, Moench TR, Cone RA Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. (2013) PLoS One. 2013 Nov 6;8(11).

  • Wang, Y.Y., A. Kannan, K.L. Nunn, M.A. Murphy, D.B. Subramani, T. Moench, R. Cone, and S.K. Lai, IgG in cervicovaginal mucus traps HSV and prevents vaginal herpes infections. Mucosal Immunology, 2014. 7(5): p. 1036-44.

  • Chen, A., S.A. McKinley, S. Wang, F. Shi, P.J. Mucha, M.G. Forest, and S.K. Lai, Transient antibodymucin interactions produce a dynamic molecular shield against viral invasion. Biophys J, 2014. 106(9): p. 2028-36.

  • Wessler T, Chen A, McKinley SA, Cone R, Forest MG, Lai SK. (2015) Using computational modeling to optimize the design of antibodies that trap viruses in mucus.  ACS Infectious Disease. 2(1):82-92 

  • Wang YY, Schroeder H, Nunn KL, Woods K, Anderson DJ, Lai SK, Cone RA. (2016) Diffusion of Immunoglobulin G in shed vaginal epithelial cells and in cell-1 free regions of human cervicovaginal mucus.  PLoS ONE. 11(6): e0158338

  • Henry C, Wang YY, Yang Q, Hoang T, Hoen T, Ensign L, Nunn KL, Schroeder H, McCallen J, Moench T, Cone R, Roffler S, Lai SK. (2016) Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus.  Acta Biomaterialia 43:61-70

  • Tachedjian G, Aldunate M, Bradshaw CS, Cone RA. (2017) The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Res Microbiol. Nov-Dec;168(9-10):782-792.

  • Wang YY*, Harit D*, Subramani DB, Arora H, Kumar P, Lai SK. (2017) Influenza-binding antibodies immobilise influenza viruses in fresh human airway mucus. European Respiratory Journal 49:1601709. 

  • Newby J*, Schiller J*, Wessler T, Edelstein J, Forest MG, Lai SK.  (2017) A blueprint for robust crosslinking of mobile species in biogels using third-party molecular anchors with short-lived anchor-matrix bonds. Nature Communications. 8(1):833

  • Yang B, Schaefer A, Wang YY, McCallen JD, Lee P, Newby J, Arora H, Kumar PA, Zeitlin L, Whaley KJ, McKinley SA, Fischer W, Harit D, Lai SK. (2018) ZMapp Reinforces the Airway Mucosal Barrier Against Ebola Virus.  Journal of Infectious Disease. 218(6):901-910

  • Schroeder HA, Nunn KL, Schaefer A, Henry CE, Lam F, Pauly MH, Whaley KJ, Zeitlin L, Humphrys MS, Ravel J, Lai SK. (2018) Herpes simplex virus binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition.  Mucosal Immunology. 11:1477–1486

  • Schiller JL, Marvin A, McCallen JD, Lai SK. (2019)  Robust antigen-specific tuning of the nanoscale barrier properties of biogels using matrix-associating IgG and IgM antibodies.  Acta Biomaterialia. 89:95-103

  • Zhu F, Jay M, Schiller JL, Schroeder HA, Wessler T, Chen A, Forest MG, Lai SK. (2019)  Modeling barrier properties of intestinal mucus reinforced with IgG and secretory IgA against motile bacteria. ACS Infectious Disease. 5(9):1570-1580  

  • Schiller JL, Fogle MM, Bussey O, Kissner WJ, Hill DB, Lai SK. (2019) Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds. Acta Biomaterialia. 107:91-101

  • Schroeder HA, Newby J, Schaefer A, Subramani B, Tubbs A, Forest MG, Miao E, Lai SK. (2020)  LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus.  Mucosal

  • Schiller JL, Lai SK. (2020) Tuning Barrier Properties of Biological Hydrogels. ACS Applied Bio Materials. 3(5) 2875–2890

  • Schaefer A, Lai SK. (2021) The biophysical principles underpinning muco-trapping functions of antibodies.  Human Vaccines & Immunotherapeutics. 1-10

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